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research article

Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets

Moser, Simone  
•
Johnsson, Kai  
2013
Chembiochem

Mycobacterium goes yeast: Target deconvolution of anti-tuberculosis drugs can be a very challenging task. Here we report a yeast 3-hybrid system that allows promising small molecules to be screened for protein targets of a pathogen in nontoxic yeast cells. The system employs libraries of randomly fragmented bacterial DNA and offers a technically simple alternative approach for target identification. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Type
research article
DOI
10.1002/cbic.201300472
Web of Science ID

WOS:000330181300002

Author(s)
Moser, Simone  
Johnsson, Kai  
Date Issued

2013

Publisher

Wiley-V C H Verlag Gmbh

Published in
Chembiochem
Volume

14

Issue

17

Start page

2239

End page

2242

Subjects

genomic library

•

snap-tag

•

target deconvolution

•

tuberculosis

•

yeast three-hybrid system

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LIP  
Available on Infoscience
June 2, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/103799
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