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research article
Mechanism of Action of 5-Nitrothiophenes against Mycobacterium tuberculosis
On using the streptomycin-starved 18b strain as a model for nonreplicating Mycobacterium tuberculosis, we identified a 5-nitrothiophene compound as highly active but not cytotoxic. Mutants resistant to 5-nitrothiophenes were found be cross-resistant to the nitroimidazole PA-824 and unable to produce the F-420 cofactor. Furthermore, 5-nitrothiophenes were shown to be activated by the F-420-dependent nitroreductase Ddn and to release nitric oxide, a mechanism of action identical to that described for nitroimidazoles.
Type
research article
Web of Science ID
WOS:000334364300058
Authors
•
Ryabova, Olga B.
•
Chiarelli, Laurent R.
•
Riccardi, Giovanna
•
Makarov, Vadim
•
Publication date
2014
Publisher
Published in
Volume
58
Issue
5
Start page
2944
End page
2947
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
May 26, 2014
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