DNA sensing unchained

In two recent reports in Science, James Chen and colleagues provide compelling evidence that detection of cytosolic DNA triggers the production of a novel second messenger, cyclic GMP-AMP (cGAMP), which in turn activates a signaling pathway that induces type I interferons (IFNs) in a STING-dependent manner. They further unravel a key role for a so far uncharacterized murine protein E330016A19 (human homolog: C6ORF150), now termed cGAMP synthetase (cGAS), to act as the DNA sensor that generates cGAMP.


Published in:
Cell research, 23, 5, 585-7
Year:
2013
ISSN:
1748-7838
Laboratories:




 Record created 2014-05-19, last modified 2018-03-17

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