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  4. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
 
research article

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

Ablasser, Andrea  
•
Schmid-Burgk, Jonathan L.
•
Hemmerling, Inga
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2013
Nature

The innate immune defence of multicellular organisms against microbial pathogens requires cellular collaboration. Information exchange allowing immune cells to collaborate is generally attributed to soluble protein factors secreted by pathogen-sensing cells. Cytokines, such as type I interferons (IFNs), serve to alert non-infected cells to the possibility of pathogen challenge. Moreover, in conjunction with chemokines they can instruct specialized immune cells to contain and eradicate microbial infection. Several receptors and signalling pathways exist that couple pathogen sensing to the induction of cytokines, whereas cytosolic recognition of nucleic acids seems to be exquisitely important for the activation of type I IFNs, master regulators of antiviral immunity. Cytosolic DNA is sensed by the receptor cyclic GMP-AMP (cGAMP) synthase (cGAS), which catalyses the synthesis of the second messenger cGAMP(2'-5'). This molecule in turn activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs. Here we find in murine and human cells that cGAS-synthesized cGAMP(2'-5') is transferred from producing cells to neighbouring cells through gap junctions, where it promotes STING activation and thus antiviral immunity independently of type I IFN signalling. In line with the limited cargo specificity of connexins, the proteins that assemble gap junction channels, most connexins tested were able to confer this bystander immunity, thus indicating a broad physiological relevance of this local immune collaboration. Collectively, these observations identify cGAS-triggered cGAMP(2'-5') transfer as a novel host strategy that serves to rapidly convey antiviral immunity in a transcription-independent, horizontal manner.

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Type
research article
DOI
10.1038/nature12640
Author(s)
Ablasser, Andrea  
Schmid-Burgk, Jonathan L.
Hemmerling, Inga
Horvath, Gabor L.
Schmidt, Tobias
Latz, Eicke
Hornung, Veit
Date Issued

2013

Published in
Nature
Volume

503

Issue

7477

Start page

530

End page

4

Subjects

Cell Communication

Note

Letter

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPABLASSER  
Available on Infoscience
May 19, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/103363
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