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research article
Phosphoric Acid Catalyzed Diastereo- and Enantioselective Synthesis of Substituted 1,3-Diaminotetralins
2014
The reaction of anilines and phenylacetaldehydes in the presence of chiral phosphoric acid afforded optically active 1,2-trans, 2,3-cis 1,3-diaminotetralins in high yields with excellent diastereo- and enantioselectivities. The trans/cis product was readily isomerized to a trans/trans stereoisomer with no significant loss of enantiomeric purity.
Type
research article
Web of Science ID
WOS:000335491000065
Authors
Publication date
2014
Publisher
Published in
Volume
16
Issue
9
Start page
2554
End page
2557
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
May 14, 2014
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