Phosphoric Acid Catalyzed Diastereo- and Enantioselective Synthesis of Substituted 1,3-Diaminotetralins

The reaction of anilines and phenylacetaldehydes in the presence of chiral phosphoric acid afforded optically active 1,2-trans, 2,3-cis 1,3-diaminotetralins in high yields with excellent diastereo- and enantioselectivities. The trans/cis product was readily isomerized to a trans/trans stereoisomer with no significant loss of enantiomeric purity.


Published in:
Organic Letters, 16, 9, 2554-2557
Year:
2014
Publisher:
Washington, Amer Chemical Soc
ISSN:
1523-7052
Laboratories:




 Record created 2014-05-14, last modified 2018-03-17


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