research article
Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251
The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.
Type
research article
Web of Science ID
WOS:000333662700018
Author(s)
Sieber, Simon
Wirthensohn, Silvan
Blom, Judith F.
Da Silva, Laeticia
Baudat, Emilie
Kaiser, Marcel
Brun, Reto
Date Issued
2014
Publisher
Published in
Volume
77
Issue
3
Start page
557
End page
562
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
May 2, 2014
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