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research article
Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251
The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.
Use this identifier to reference this record
Type
research article
Web of Science ID
WOS:000333662700018
Authors
•
Sieber, Simon
•
Wirthensohn, Silvan
•
Blom, Judith F.
•
Da Silva, Laeticia
•
Baudat, Emilie
•
Kaiser, Marcel
•
Brun, Reto
•
Publication date
2014
Publisher
Published in
Volume
77
Issue
3
Start page
557
End page
562
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
May 2, 2014