Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules.


Published in:
Nanoscale, 6, 5, 2929-2936
Year:
2014
Publisher:
Cambridge, Royal Society of Chemistry
ISSN:
2040-3364
Laboratories:




 Record created 2014-04-02, last modified 2018-03-17


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