Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

• Published in: Nanoscale (ISSN: 2040-3364), vol. 6, num. 5, p. 2929-2936
• Cambridge: Royal Society of Chemistry, 2014

A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules.

Reference

• EPFL-ARTICLE-198115
• doi:10.1039/c3nr05897b
• View record in Web of Science

Record created on 2014-04-02, modified on 2017-05-12