research article
Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples
2014
A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules.
Type
research article
Web of Science ID
WOS:000332127200056
Author(s)
Magouroux, Thibaud
Schwung, Sebastian
Dubled, Marc
Schneiter, Guillaume Stephane
Rytz, Daniel
Bonacina, Luigi
Wolf, Jean-Pierre
Date Issued
2014
Publisher
Published in
Volume
6
Issue
5
Start page
2929
End page
2936
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
April 2, 2014
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