Method of enhancing proliferation and/or hematopoietic differentiation of stem cells
The present invention provides methods for inducing differentiation of a stem cell, such as an embryonic stem cell, into a hematopoietic stem cell, by expressing a cdx gene and/or a hox gene. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood cell lineages. This is desirable where a mammal has suffered a decrease in hematopoietic or mature blood cells as a consequence of disease, radiation or chemotherapy
37595785
Also published as: WO2007002167 (A9); WO2007002167 (A3); WO2007002167 (A8); US2010209396 (A1)
Patent number | Country code | Kind code | Date issued |
US2010209396 | US | A1 | 2010-08-19 |
WO2007002167 | WO | A8 | 2007-08-23 |
WO2007002167 | WO | A3 | 2007-06-21 |
WO2007002167 | WO | A9 | 2007-03-15 |
WO2007002167 | WO | A2 | 2007-01-04 |