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research article
Synthesis Of Pyrrolidine 3,4-Diol Derivatives With Anticancer Activity On Pancreatic Tumor Cells
2014
Novel pyrrolidine 3,4-diol derivatives of the type (2R and 2S,3R,45){[(( 1R)-1-methoxycarbonyl and hydroxylmethyl)-1-arylmethyl)amino] ethyl}-pyrrolidine-3,4-diol have been prepared and evaluated as a-mannosidase inhibitors and assayed for their anticancer activity in vitro. They all exhibit specific but moderate activity as inhibitors towards a-mannosidase from Jack beans. Compounds 7 and 8b bearing hydroxymethyl and trifluoromethylbiphenyl groups show the best antiproliferative effect in two pancreatic cancer cell lines.
Use this identifier to reference this record
Type
research article
Web of Science ID
WOS:000330084900043
Authors
Steimer, Frederic
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Moreno-Vargas, Antonio J.
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Caffa, Irene
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Cea, Michele
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Montecucco, Fabrizio
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Nencioni, Alessi
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Robina, Inmaculada
Publication date
2014
Publisher
Published in
Volume
88
Issue
2
Start page
1445
End page
1464
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
March 3, 2014