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research article
Synthesis Of Pyrrolidine 3,4-Diol Derivatives With Anticancer Activity On Pancreatic Tumor Cells
2014
Novel pyrrolidine 3,4-diol derivatives of the type (2R and 2S,3R,45){[(( 1R)-1-methoxycarbonyl and hydroxylmethyl)-1-arylmethyl)amino] ethyl}-pyrrolidine-3,4-diol have been prepared and evaluated as a-mannosidase inhibitors and assayed for their anticancer activity in vitro. They all exhibit specific but moderate activity as inhibitors towards a-mannosidase from Jack beans. Compounds 7 and 8b bearing hydroxymethyl and trifluoromethylbiphenyl groups show the best antiproliferative effect in two pancreatic cancer cell lines.
Type
research article
Web of Science ID
WOS:000330084900043
Authors
Steimer, Frederic
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Moreno-Vargas, Antonio J.
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Caffa, Irene
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Cea, Michele
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Montecucco, Fabrizio
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Nencioni, Alessi
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Robina, Inmaculada
Publication date
2014
Publisher
Published in
Volume
88
Issue
2
Start page
1445
End page
1464
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
March 3, 2014
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