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research article
Amides in One Pot from Carboxylic Acids and Amines via Sulfinylamides
2014
An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2-ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their alpha-epimerization.
Type
research article
Web of Science ID
WOS:000330098400071
Authors
Publication date
2014
Publisher
Published in
Volume
16
Issue
2
Start page
604
End page
607
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
March 3, 2014
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