Amides in One Pot from Carboxylic Acids and Amines via Sulfinylamides

An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2-ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their alpha-epimerization.


Published in:
Organic Letters, 16, 2, 604-607
Year:
2014
Publisher:
Washington, Amer Chemical Soc
ISSN:
1523-7060
Laboratories:




 Record created 2014-03-03, last modified 2018-03-17


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