Study of the stability of the 5-aminolevulinic acid tyrosine ester in aqueous solution

Photodynamic therapy based on photoactivable porphyrins (PAPs) can treat various dermatological conditions. The side-effects as well as the non-selective or insufficient accumulation of PAPs in the targeted tissues limit performances. We studied the stability in solution at different temperatures (21 degrees C; 4 degrees C), different pH values (7.5; 2.0), and as a function of time of 5-aminolevulinic acid's Tyrosine-ester, a molecule presenting interesting properties to selectively produce PAPs in blood vessels after topical application. Solutions of this precursor can be kept up to 24 h at refrigerated temperatures and under acidic pH. At room temperature or physiological pH, they must be prepared minutes before their use.


Published in:
ARKIVOC - Online Journal of Organic Chemistry, 2014, 3, 228-238
Year:
2014
ISSN:
1424-6376
Keywords:
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 Record created 2014-01-27, last modified 2018-09-13

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