Loading...
research article
Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin
2013
Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. In this work, we show how atomic force microscopy in liquid can characterize, through time-lapse imaging, the dynamical influence of intercalating agents on the supercoiling of DNA, improving our understanding of the drug's effect.
Type
research article
Web of Science ID
WOS:000327111700107
Authors
Publication date
2013
Publisher
Published in
Volume
13
Issue
11
Start page
5679
End page
5684
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
January 9, 2014
Use this identifier to reference this record