Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin

Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. In this work, we show how atomic force microscopy in liquid can characterize, through time-lapse imaging, the dynamical influence of intercalating agents on the supercoiling of DNA, improving our understanding of the drug's effect.


Published in:
Nano Letters, 13, 11, 5679-5684
Year:
2013
Publisher:
Washington, American Chemical Society
ISSN:
1530-6984
Keywords:
Laboratories:




 Record created 2014-01-09, last modified 2018-03-17


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