Amide bond formation via C(sp(3))-H bond functionalization and CO insertion

Liu, Huizhen; Laurenczy, Gabor; Yan, Ning; Dyson, Paul J.

doi:10.1039/c3cc47015f

research article

Amide bond formation via C(sp(3))-H bond functionalization and CO insertion

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2014

Chemical Communications (ChemComm)

An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp(3))-H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes.

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Amide bond formation via C(sp(3))-H bond functionalization and CO insertion.pdf

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openaccess

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CC BY

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