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research article
Palladium(II)-Catalyzed Cyclizative Cross-Coupling of ortho-Alkynylanilines with ortho-Alkynylbenzamides under Aerobic Conditions
Born to couple: The Pd(OAc)2-catalyzed reaction of o-alkynylanilines (1) with oalkynylbenzamides (2) affords the cyclizative cross-coupling products 3 in good to excellent yields. Three bonds are created in the formation of two heterocycles tethered by a tetra substituted double bond. Mechanistic studies indicate that the reaction is initiated by aminopalladation with subsequent oxypalladation, N-demethylation, and reductive elimination
Type
research article
Web of Science ID
WOS:000327410300042
Authors
Publication date
2013
Publisher
Published in
Volume
52
Issue
49
Start page
12992
End page
12996
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 11, 2013
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