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  4. Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy
 
research article

Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy

Piffaretti, Filippo
•
Zellweger, Matthieu  
•
Kasraee, Behrooz
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2013
Dermatology

Background: Photodynamic therapy (PDT) with Metvix® is a good therapeutic option to treat actinic keratosis, but it presents drawbacks (pain, lesion recurrences, heterogeneous outcome), emphasizing the possible need to individualize treatment. Objective: We assessed whether PDT clinical outcome and pain during treatment were correlated with protoporphyrin IX fluorescence intensity and photobleaching. Methods: 25 patients were treated by Metvix PDT. The outcome was evaluated after 1.3 (±0.4), 7.6 (±1.8), 13.2 (±1.2) and 33.6 (±3.0) months. After administration of Metvix, red light (632 ± 10 nm) was delivered with a light-emitting diode panel device. The outcome was assessed on a cosmetoclinical scale. Results: All patients who showed a fluorescence level before PDT treatment above a certain threshold had a complete recovery at 33.6 (±3.0) months. Conclusion: Our approach could be used to individualize PDT treatment based on the pretreatment fluorescence level, and to predict its long-term outcome. © 2013 S. Karger AG, Basel

  • Details
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Type
research article
DOI
10.1159/000353775
Web of Science ID

WOS:000327675500005

Author(s)
Piffaretti, Filippo
Zellweger, Matthieu  
Kasraee, Behrooz
Barge, Jérôme
Salomon, Denis
Van Den Bergh, Hubert  
Wagnières, Georges  
Date Issued

2013

Publisher

Karger

Published in
Dermatology
Volume

227

Issue

3

Start page

214

End page

225

Subjects

Fluorescence

•

Imaging

•

Protoporphyrin IX

•

Actinic keratosis

•

Photodynamic therapy

•

Metvix (R)

•

Pain

•

Bleaching

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

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LCOM  
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Available on Infoscience
November 25, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/97218
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