Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy

• Published in: Dermatology (ISSN: 1018-8665), vol. 227, num. 3, p. 214-225
• Karger, 2013

Background: Photodynamic therapy (PDT) with Metvix® is a good therapeutic option to treat actinic keratosis, but it presents drawbacks (pain, lesion recurrences, heterogeneous outcome), emphasizing the possible need to individualize treatment. Objective: We assessed whether PDT clinical outcome and pain during treatment were correlated with protoporphyrin IX fluorescence intensity and photobleaching. Methods: 25 patients were treated by Metvix PDT. The outcome was evaluated after 1.3 (±0.4), 7.6 (±1.8), 13.2 (±1.2) and 33.6 (±3.0) months. After administration of Metvix, red light (632 ± 10 nm) was delivered with a light-emitting diode panel device. The outcome was assessed on a cosmetoclinical scale. Results: All patients who showed a fluorescence level before PDT treatment above a certain threshold had a complete recovery at 33.6 (±3.0) months. Conclusion: Our approach could be used to individualize PDT treatment based on the pretreatment fluorescence level, and to predict its long-term outcome. © 2013 S. Karger AG, Basel

Keywords: Fluorescence ; Imaging ; Protoporphyrin IX ; Actinic keratosis ; Photodynamic therapy ; Metvix (R) ; Pain ; Bleaching

Reference

• EPFL-ARTICLE-190679
• doi:10.1159/000353775
• View record in Web of Science

Record created on 2013-11-25, modified on 2017-05-12