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research article
Catalytic Enantioselective Michael Addition of α-Aryl-α-Isocyanoacetates to Vinyl Selenone: Synthesis of α,α-Disubstituted α-Amino Acids and (+)- and (−)-Trigonoliimine A
Be like Mike: The title reaction in the presence of the catalyst 1 afforded Michael adducts in excellent yields and enantioselectivities. The adducts were readily converted into alpha,alpha’-disubstituted alpha-amino acids. The enantioselective total synthesis of both (+)- and (-)-trigonoliimine A was accomplished using one of the Michael adducts derived from this methodology.
Type
research article
Web of Science ID
WOS:000327582900047
Authors
Publication date
2013
Publisher
Published in
Volume
52
Issue
48
Start page
12714
End page
12718
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 20, 2013
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