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To overcome the problem of outlier data in the regression analysis for numerical-based damage spectra, the C4.5 decision tree learning algorithm is used to predict damage in reinforced concrete buildings in future earthquake scenarios. Reinforced concrete buildings are modelled as single-degree-of-freedom systems and various time-history nonlinear analyses are performed to create a dataset of damage indices. Subsequently, two decision trees are trained using the qualitative interpretations of those indices. The first decision tree determines whether damage occurs in an RC building. Consequently, the second decision tree predicts the severity of damage as repairable, beyond repair, or collapse.