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research article
Heteroannulation of arynes with N-aryl-α-aminoketones for the synthesis of unsymmetrical N-aryl-2,3-disubstituted indoles: an aryne twist of Bischler–Möhlau indole synthesis
Reaction of 2-(trimethylsilyl)aryl triflates 1 with N-aryl-a-amino ketones 2 afforded N-aryl-2,3-disubstituted indoles in good to excellent yields with complete control of the substitution patterns. This methodology allowed for the first time a one-step synthesis of unsymmetrical 2,3-dialkyl substituted indoles in a regiospecific manner.
Type
research article
Web of Science ID
WOS:000325643500024
Authors
Publication date
2013
Publisher
Published in
Volume
49
Issue
87
Article Number
10284
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 15, 2013
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