Loading...
research article
One-pot squaric acid diester mediated aqueous protein conjugation
A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e. g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.
Type
research article
Web of Science ID
WOS:000322915200017
Authors
Publication date
2013
Publisher
Published in
Volume
49
Issue
71
Start page
7815
End page
7817
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 1, 2013
Use this identifier to reference this record