One-pot squaric acid diester mediated aqueous protein conjugation

A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e. g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.


Published in:
Chemical Communications, 49, 71, 7815-7817
Year:
2013
Publisher:
Cambridge, Royal Soc Chemistry
ISSN:
1359-7345
Laboratories:




 Record created 2013-10-01, last modified 2018-09-13


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)