Catalytic Friedel-Crafts Reaction of Aminocyclopropanes

A Lewis acid catalyzed Friedel-Crafts reaction between donor-acceptor aminocyclopropanes and indoles and other electron-rich aromatic compounds is reported. Indole alkylation at the C3 position was generally obtained for a broad range of functional groups and substitution patterns. In the case of C3-substituted indoles, C2 alkylation was observed. The reaction gives a rapid access to gamma amino acid derivatives present in numerous bioactive molecules.


Published in:
Organic Letters, 15, 14, 3738-3741
Year:
2013
Publisher:
Washington, American Chemical Society
ISSN:
1523-7060
Laboratories:




 Record created 2013-10-01, last modified 2018-01-28

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