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research article
Amide Formation in One Pot from Carboxylic Acids and Amines via Carboxyl and Sulfinyl Mixed Anhydrides
2013
An efficient method has been developed for the preparation of yet unknown acyclic mixed anhydrides of carboxylic and sulfinic acids. Sterically hindered 2-methylbut-3-ene-2-sulfinyl carboxylates add primary and secondary amines preferentially onto the carbonyl moieties realizing a new method for the one-pot preparation of carboxamides. It uses 1:1 mixtures of carboxylic acids and amines without a base, requires no excess of reagents, and liberates only volatile coproducts. Protected di- and tripeptides have been prepared in solution without epimerization by application of this method.
Type
research article
Web of Science ID
WOS:000319720900057
Authors
Zambron, Bartosz K.
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Moreno-Clavijo, Elena
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Publication date
2013
Publisher
Published in
Volume
15
Issue
10
Start page
2550
End page
2553
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 1, 2013
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