Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens

• Published in: Nature Reviews Microbiology (ISSN: 1740-1526), vol. 11, num. 6, p. 365-369
• London: Nature Publishing Group, 2013

Activation of most major innate immune signalling cascades relies on the detection of microorganisms or their associated danger signals by host pattern recognition molecules. A flurry of recent studies has now uncovered a role for host translation inhibition in innate immune surveillance and the detection of bacterial pathogens. Here, we present the main findings from these studies and discuss whether translation inhibition is an alarm signal that directly drives innate immune responses to bacterial pathogens, or rather one component of a more general metabolic stress response to infection.

Reference

• EPFL-REVIEW-189045
• doi:10.1038/nrmicro3029
• View record in Web of Science

Record created on 2013-10-01, modified on 2017-05-12