Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Sensitivity Enhancement in 1D Heteronuclear NMR Spectroscopy via Single-Scan Inverse Experiments
 
research article

Sensitivity Enhancement in 1D Heteronuclear NMR Spectroscopy via Single-Scan Inverse Experiments

Mishkovsky, Mor  
•
Frydman, Lucio
2004
ChemPhysChem

Measuring the nuclear magnetic resonance spectra of low-gamma heteronuclei such as N-15 constitutes an important analytical tool for the characterization of molecular structure and dynamics. The reduced resonance frequencies and magnetic moments of these heteronuclei, however, make the sensitivity of this kind of spectroscopy inherently lower than that of comparable H-1 NMR observations. A well-known solution to this sensitivity problem is indirect detection: a 2D NMR technique capable of enhancing the sensitivity of heteronuclear NMR by porting the actual data acquisition from the low-gamma nucleus to neighboring protons. This has become the standard method of observation in biomolecular NMR, where the resolution introduced by 2D spectroscopy is always a sought-after commodity. Indirect detection, however, has not gained a wide appeal in organic chemistry or in in vivo investigations, where one-dimensional heteronuclear NMR information usually suffices. The present study explores the possibility of retaining certain advantages derived from indirect detection while not giving up on the simple one-dimensional nature of heteronuclear NMR, by relying on the spatial-encoding scheme we have recently demonstrated for implementing single-scan multi-dimensional NMR spectroscopy. Preliminary results based on a 1D N-15 NMR can be enhanced significantly in this manner; the relevance of this experiment given the advent of dedicated H-1-observing cryogenic probeheads with very high sensitivities is briefly discussed.

  • Details
  • Metrics
Type
research article
DOI
10.1002/cphc.200400005
Author(s)
Mishkovsky, Mor  
Frydman, Lucio
Date Issued

2004

Published in
ChemPhysChem
Volume

5

Issue

6

Start page

779

End page

786

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
IPSB  
Available on Infoscience
September 25, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/94935
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés