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research article

iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks

Rockel, S.
•
Geertz, M.
•
Hens, K.  
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2013
Nucleic Acids Research

Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes.

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Nucl. Acids Res.-2013-Rockel-e52.pdf

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Publisher's Version

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http://purl.org/coar/version/c_970fb48d4fbd8a85

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openaccess

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2.1 MB

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Adobe PDF

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d8123054c09d7b940a7934e5e2277478

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