iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks

Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes.


Published in:
Nucleic Acids Research, 41, 4, e52
Year:
2013
Publisher:
Oxford, Oxford University Press
ISSN:
1362-4962
Laboratories:




 Record created 2013-05-17, last modified 2018-09-13

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