Synthesis of Iminonitriles by Oxone/TBAB-Mediated One-Pot Oxidative Three-Component Strecker Reaction

Oxidative three-component reaction of aldehydes, amines, and TMSCN in a biphasic solvent system (toluene/H2O) containing Oxone, tetra-n-butylammonium bromide (TBAB) and sodium bicarbonate afforded α-iminonitriles in good to excellent yields. This oxidative Strecker reaction was applicable to a wide range of aldehydes and amines, aromatic or aliphatic, of different electronic and steric properties. Substituted 1-aza-2-cyano-1,3-dienes were also accessible using α,β-unsaturated aldehydes as inputs.


Published in:
Synthesis, 45, 10, 1380-1386
Year:
2013
Publisher:
Stuttgart, Georg Thieme Verlag Kg
ISSN:
1437-210X
Keywords:
Laboratories:




 Record created 2013-05-14, last modified 2018-09-13


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