Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation

The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp(3))-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of heteroaromatics to access functionalized indoline scaffolds in a single step.


Published in:
Organic Letters, 15, 6, 1354-1357
Year:
2013
Publisher:
Washington, Amer Chemical Soc
ISSN:
1523-7060
Laboratories:




 Record created 2013-05-13, last modified 2018-03-17


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