000184761 001__ 184761
000184761 005__ 20181114202419.0
000184761 0247_ $$2doi$$a10.1371/journal.pone.0056871
000184761 022__ $$a1932-6203
000184761 02470 $$2ISI$$a000316658800044
000184761 037__ $$aARTICLE
000184761 245__ $$aHippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats
000184761 269__ $$a2013
000184761 260__ $$aSan Francisco$$bPublic Library of Science$$c2013
000184761 300__ $$a10
000184761 336__ $$aJournal Articles
000184761 520__ $$aDisturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested as potential factors underlying disorders like autism and schizophrenia resulting in associated behavioral alterations including changes in social and emotional behavior as well as abnormal aggression. Neuronal cell adhesion molecules (nCAMs) and mutations in these genes were found to be strongly implicated in the pathophysiology of these disorders. Neuroligin2 (nlgn2) is a postsynaptic cell adhesion molecule, which is predominantly expressed at inhibitory synapses and required for synapse specification and stabilization. Changes in the expression of nlgn2 were shown to result in alterations of social behavior as well as altered inhibitory synaptic transmission, hence modifying the E/I balance. In our study, we focused on the role of nlgn2 in the dorsal hippocampus in the regulation of emotional and social behaviors. To this purpose, we injected an AAV construct overexpressing nlgn2 in the hippocampus of rats and investigated the effects on behavior and on markers for the E/I ratio. We could show an increase in GAD65, a GABA-synthesizing protein in neuronal terminals, and furthermore, reduced exploration of novel stimuli and less offensive behavior. Our data suggest nlgn2 in the hippocampus to be strongly implicated in maintaining the E/I balance in the brain and thereby modulating social and emotional behavior.
000184761 700__ $$0245394$$aKohl, Christine$$g213704
000184761 700__ $$0245992$$aRiccio, Orbicia$$g220575
000184761 700__ $$aGrosse, Jocelyn
000184761 700__ $$aZanoletti, Olivia
000184761 700__ $$aFournier, Céline
000184761 700__ $$aSchmidt, Mathias V.
000184761 700__ $$0243016$$aSandi, Carmen$$g160090
000184761 773__ $$j8$$k2$$qe56871$$tPLoS ONE
000184761 8564_ $$s711879$$uhttps://infoscience.epfl.ch/record/184761/files/Kohl-Hippocampal%20Neuroligin-2%20Overexpression.pdf$$yn/a$$zn/a
000184761 909C0 $$0252121$$pLGC$$xU10913
000184761 909CO $$ooai:infoscience.tind.io:184761$$pSV$$particle$$qGLOBAL_SET
000184761 917Z8 $$x192880
000184761 917Z8 $$x192880
000184761 917Z8 $$x192880
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000184761 917Z8 $$x192880
000184761 937__ $$aEPFL-ARTICLE-184761
000184761 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000184761 980__ $$aARTICLE