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review article
Pathogenic Pore-Forming Proteins: Function and Host Response
2012
Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.
Type
review article
Web of Science ID
WOS:000309947900004
Authors
Publication date
2012
Publisher
Published in
Volume
12
Issue
3
Start page
266
End page
275
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 27, 2013
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