Pathogenic Pore-Forming Proteins: Function and Host Response

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.


Published in:
Cell Host & Microbe, 12, 3, 266-275
Year:
2012
Publisher:
Cambridge, Cell Press
ISSN:
1931-3128
Laboratories:


Note: The status of this file is: Involved Laboratories Only


 Record created 2013-02-27, last modified 2018-03-17

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