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research article

Delocalized surface modes reveal three-dimensional structures of complex biomolecules

Sugiharto, A. B.
•
Johnson, C. M.
•
Dunlop, I. E.
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2008
Journal of Physical Chemistry C

Interfaces are important for many processes in chemistry, physics, and biology. Crucial to their properties are the details of the three-dimensional structure of the participating (macro)molecules. Vibrational Sum Frequency Generation (VSFG) is a tool specifically suited to probing the first few atomic layers of an interface. Traditionally, interfaces are probed by mapping localized vibrational modes. Here, we show that the three-dimensional structure of large interfacial biomolecules can be probed by measuring delocalized vibrational backbone modes, which appear to be extremely sensitive to changes in the skeletal structure. We demonstrate that for three different films of chemically identical poly(lactic acid) polymer, we can observe dramatic changes in the three-dimensional arrangement of the surface molecular backbones. This type of information could not be obtained from probing only localized group modes. © 2008 American Chemical Society.

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Type
research article
DOI
10.1021/jp801254y
Scopus ID

2-s2.0-53349146551

Author(s)
Sugiharto, A. B.
Johnson, C. M.
Dunlop, I. E.
Roke, S.  
Date Issued

2008

Published in
Journal of Physical Chemistry C
Volume

112

Issue

20

Start page

7531

End page

7534

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
LBP  
Available on Infoscience
February 8, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/88734
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