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  4. Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus
 
research article

Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus

Markram, H  
•
Segal, M
1990
Neuroscience letters

The effect of acetylcholine (ACh) on intracellular responses to ionophoretic application of N-methyl-D-aspartate (NMDA) was examined in rat hippocampal slice. Recordings were obtained from CA1 neurons under current- and voltage-clamp conditions. Drugs were applied topically by ionophoretic and microdrop techniques. ACh produced an atropine-sensitive potentiation of responses to NMDA. The effect of ACh on NMDA receptor-mediated responses was independent of changes in voltage or potassium conductances caused by ACh. ACh also potentiated responses to L-glutamate but not to kainate or quisqualate. This effect was blocked by DL-2-amino-5-phosphonovalerate (2-APV), an NMDA receptor antagonist. We conclude that ACh, acting on muscarinic receptors, potentiates selectively, the NMDA subclass of L-glutamate receptor.

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Type
research article
PubMed ID

1973273

Author(s)
Markram, H  
Segal, M
Date Issued

1990

Published in
Neuroscience letters
Volume

113

Issue

1

Start page

62

End page

5

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LNMC  
Available on Infoscience
January 28, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/88314
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