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  4. Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex
 
research article

Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex

Gupta, A.  
•
Wang, Y.
•
Markram, H.  
2000
Science

A puzzling feature of the neocortex is the rich array of inhibitory interneurons. Multiple neuron recordings revealed numerous electrophysiological-anatomical subclasses of neocortical gamma-aminobutyric acid-ergic (GABAergic) interneurons and three types of GABAergic synapses. The type of synapse used by each interneuron to influence its neighbors follows three functional organizing principles. These principles suggest that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable combinatorial inhibitory effects in the neocortex.

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Type
research article
DOI
10.1126/science.287.5451.273
PubMed ID

10634775

Author(s)
Gupta, A.  
Wang, Y.
Markram, H.  
Date Issued

2000

Publisher

American Association for the Advancement of Science

Published in
Science
Volume

287

Issue

5451

Start page

273

End page

278

Subjects

Neural Inhibition

•

Synaptic Transmission

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LNMC  
Available on Infoscience
January 28, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/88288
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