Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex

A puzzling feature of the neocortex is the rich array of inhibitory interneurons. Multiple neuron recordings revealed numerous electrophysiological-anatomical subclasses of neocortical gamma-aminobutyric acid-ergic (GABAergic) interneurons and three types of GABAergic synapses. The type of synapse used by each interneuron to influence its neighbors follows three functional organizing principles. These principles suggest that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable combinatorial inhibitory effects in the neocortex.


Published in:
Science (New York, N.Y.), 287, 5451, 273-8
Year:
2000
ISSN:
0036-8075
Keywords:
Other identifiers:
Laboratories:




 Record created 2013-01-28, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)