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research article
Copper Catalyzed N-Arylation of Amidines with Aryl Boronic Acids and One-Pot Synthesis of Benzimidazoles by a Chan–Lam–Evans N-Arylation and C–H Activation/C–N Bond Forming Process
2012
Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu(OAc)2 and NaOPiv under mild aerobic conditions. Combining this step with an intramolecular direct CH bond functionalization, catalyzed by the same catalytic system but under oxygen at 120 °C, afforded benzimidazoles 3 in good to excellent yields.
Type
research article
Web of Science ID
WOS:000311926000043
Authors
Publication date
2012
Publisher
Published in
Volume
14
Issue
23
Start page
5980
End page
5983
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 9, 2012
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