Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells

Neuregulins are growth factors that are essential for myogenesis and regulate muscle metabolism. The addition of a recombinant neuregulin-1 isoform, heregulin-beta1(177-244) (Hrg), containing 3 nmol/l of the bioactive epidermal growth factor-like domain, to developing L6E9 myocytes has acute and chronic effects on glucose uptake and enhances myogenesis. Here, we studied the metabolic adaptation of myocytes to chronic treatments with Hrg.


Published in:
Diabetes, 56, 9, 2185-93
Year:
2007
ISSN:
1939-327X
Laboratories:




 Record created 2012-11-08, last modified 2018-09-13


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