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research article
Chronic angiotensin II receptor blockade induces cardioprotection during ischemia by increased PKC-epsilon expression in the mouse heart
This study was performed to investigate the role of chronic pretreatment with angiotensin II type 1 receptor antagonists (ARB) and angiotensin converting enzyme inhibitors (ACE-I) in myocardial infarction (MI) and ischemic preconditioning (iPC). Little is known about molecular mechanisms of MI and iPC, especially about protein kinase C (PKC) isozyme levels induced by chronic pharmacologic pretreatment with ARB and ACE-I. To address one of the most important signal molecules in iPC, the PKC system was investigated in an ischemia/reperfusion model using isolated mouse hearts.
Type
research article
Authors
Lange, Stefan A.
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Schober, Kristin
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Wunderlich, Carsten
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Marquetant, Rainer
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Weinbrenner, Christof
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Strasser, Ruth H.
Publication date
2007
Published in
Volume
49
Issue
1
Start page
46
End page
55
Subjects
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 29, 2012
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