Exploring the therapeutic space around NAD+

NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegeneration. Here, we discuss how maintaining or raising NAD(+) levels can improve metabolism and prevent age-related functional decline and associated disease, and how basic scientific discoveries in the NAD(+) signaling pathway are being translated to the clinic.


Published in:
Journal of Cell Biology, 199, 2, 205-209
Year:
2012
Publisher:
New York, Rockefeller University Press
ISSN:
0021-9525
Laboratories:




 Record created 2012-10-21, last modified 2018-03-17

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