Chemical functionalization of bio-ceramics to enhance endothelial cells adhesion for tissue engineering

To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gallate moiety was designed, synthesized, and characterized. The binding of this ligand to alumina-based, hydroxyapatite-based, and calcium phosphate-based bioceramics was demonstrated. The conjugation of this ligand to the bioceramics induced a decrease in the nonselective and integrin-selective binding of human serum proteins, whereas the binding and adhesion of human endothelial cells was enhanced, dependent on the particular bioceramics.


Published in:
Journal of Medicinal Chemistry, 55, 7988−7997
Year:
2012
Publisher:
Washington, American Chemical Society
ISSN:
0022-2623
Laboratories:


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 Record created 2012-10-04, last modified 2018-03-17

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