The many faces of α-synuclein: from structure and toxicity to therapeutic target

Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases. The molecular mechanism (or mechanisms) through which α-syn abnormally accumulates and contributes to neurodegeneration in these disorders remains unknown. Here, we provide an overview of current knowledge and prevailing hypotheses regarding the conformational, oligomerization and aggregation states of α-syn and their role in regulating α-syn function in health and disease. Understanding the nature of the various α-syn structures, how they are formed and their relative contributions to α-syn-mediated toxicity may inform future studies aiming to develop therapeutic prevention and intervention.


Published in:
Nature reviews. Neuroscience, 14, 1, 38-48
Year:
2013
Publisher:
London, Nature Publishing Group
ISSN:
1471-0048
Laboratories:




 Record created 2012-09-21, last modified 2018-03-17

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