Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity

Aggravating aggregation: an N-terminal domain that is in close proximity to the polyQ domain in the huntingtin protein, htt105-138, is shown to be highly aggregation prone. Potential cross-talk between this domain and the polyQ region may play a central role in regulating the aggregation and toxicity of Htt-N-terminal fragments.


Published in:
Angewandte Chemie (International ed. in English), 52, 2, 562-7
Year:
2012
Publisher:
Weinheim, Wiley-Blackwell
ISSN:
1521-3773
Laboratories:




 Record created 2012-09-21, last modified 2018-12-03

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