Nickel-catalyzed diastereoselective alkyl-alkyl Kumada coupling

A nickel pincer complex is found to catalyze alkyl–alkyl Kumada coupling reactions of 1,3- and 1,4-substituted cyclohexyl halides and tetrahydropyrans with an excellent diastereoselectivity. The mechanistic investigation of the coupling reactions provides evidence that the activation of alkyl halides is reversible.


Published in:
Organic Letters, 14, 16, 4286-4289
Year:
2012
Publisher:
Washington, American Chemical Society
ISSN:
1523-7060
Laboratories:




 Record created 2012-08-29, last modified 2018-03-17

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