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research article
Spirocyclization by Palladium-Catalyzed Domino Heck–Direct C–H Arylation Reactions: Synthesis of Spirodihydroquinolin-2-ones
2012
Treatment of a DMA solution of anilide 1 with a catalytic amount of palladium acetate (0.025 equiv) and XPhos (0.05 equiv) in the presence of potassium carbonate (2.0 equiv) at 100 C afforded dihydroquinolin-2-ones spiro-fused to dihydrofuranyl, indolinyl, and indanyl 2 in good to excellent yields. The reaction went through a domino sequence involving a 5-exo-trig Heck cyclization followed by an intramolecular direct CH functionalization.
Type
research article
Web of Science ID
WOS:000306536500050
Authors
Publication date
2012
Published in
Volume
14
Issue
14
Start page
3760
End page
3763
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 23, 2012
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