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review article
Towards a molecular architecture of centriole assembly
The centriole is an evolutionarily conserved macromolecular structure that is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first characterized decades ago with the advent of electron microscopy, revealing a striking ninefold radial arrangement of microtubules. However, it is only recently that the molecular mechanisms governing centriole assembly have begun to emerge, including the elucidation of the crucial role of spindle assembly abnormal 6 (SAS-6) proteins in imparting the ninefold symmetry. These advances have brought the field to an exciting era in which architecture meets function.
Type
review article
Web of Science ID
WOS:000305809700010
Authors
Publication date
2012
Published in
Volume
13
Issue
7
Start page
425
End page
435
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
July 20, 2012
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