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research article
Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors
Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated azepane displayed selective, competitive, and moderate inhibition toward bovine kidney alpha-L-fucosidase. (C) 2011 Elsevier Ltd. All rights reserved.
Type
research article
Web of Science ID
WOS:000305338000011
Authors
Li, Hongqing
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Zhang, Yongmin
•
•
•
Sollogoub, Matthieu
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Bleriot, Yves
Publication date
2012
Published in
Volume
356
Start page
110
End page
114
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
July 13, 2012
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