Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors

Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated azepane displayed selective, competitive, and moderate inhibition toward bovine kidney alpha-L-fucosidase. (C) 2011 Elsevier Ltd. All rights reserved.


Published in:
Carbohydrate Research, 356, 110-114
Year:
2012
Keywords:
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 Record created 2012-07-13, last modified 2018-01-28


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