Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors
Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated azepane displayed selective, competitive, and moderate inhibition toward bovine kidney alpha-L-fucosidase. (C) 2011 Elsevier Ltd. All rights reserved.
Keywords: Iminosugar ; Glycosidase ; Inhibitor ; Azepane ; Type-2 Diabetes-Mellitus ; Alpha-Glucosidase ; Polyhydroxy Piperidines ; Selective Inhibitors ; Facile Synthesis ; Isofagomine ; Potent ; Agents ; Cation ; Ring
Record created on 2012-07-13, modified on 2016-08-09